New Techniques in Diagnostics bv Capillary Electrophoresis of Hereditarv Disorders of Purine and Pvrimidine Metabolism

Authors

  • D. Friedecky Department of Analytical Chemistry, Palacký University, Olomouc,
  • T. Adam Centre of Analytical Chemistry of Molecular Structures, Palacky University, Olomouc
  • J. Sevcik Centre of Analytical Chemistry of Molecular Structures, Palacky University, Olomouc
  • P. Bartak Centre of Analytical Chemistry of Molecular Structures, Palacky University, Olomouc

Abstract

Purine and pyrimidine compounds were analyzed by capillary electrophoresis in urine of patients with inherited disorders purine and pyrimidine metabolism. Two separation of systems (alkaline-anionic and acid-cationic mode) have been compared. The use of a strongly acidic background electrolyte (pH 1.8) improves the selectivity and informative pithiness of the method. A combination of both anionic and cationic modes increases the reliability of diagnosis in hereditary disorders.

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Published

1999-09-15

How to Cite

Friedecky, D., Adam, T., Sevcik, J., & Bartak, P. (1999). New Techniques in Diagnostics bv Capillary Electrophoresis of Hereditarv Disorders of Purine and Pvrimidine Metabolism. Chemické Listy, 93(8). Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2589

Issue

Vol. 93 No. 8 (1999)

Section

Articles